Linagliptin and Metformin Extended-Release Tablets
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Linagliptin and metformin extended-release tablets are a sustained-release combination of linagliptin and metformin hydrochloride. The indication is as an adjunct to diet and exercise for the improvement of glycemic control in adults with type 2 diabetes mellitus who are suitable for treatment with linagliptin and metformin.
Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. DPP-4 degrades incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Linagliptin increases active incretin concentrations, stimulating glucose-dependent insulin release and reducing circulating glucagon levels.
Both incretin hormones are involved in the physiological regulation of glucose homeostasis; metformin is an antihyperglycemic agent that improves glucose tolerance in patients with type 2 diabetes, reducing both fasting and postprandial glucose. It inhibits hepatic gluconeogenesis, reduces glucose absorption in the small intestine, and improves insulin sensitivity in peripheral tissues by increasing glucose uptake and utilization.
In July 2016, the annual production capacity of 300 tons of calcium hydroxymethanesulfonate raw materials workshop was successfully built, and in September of the same year, the production line of 5-nitrovanillin diethyl acetal with an annual output of 400 tons was also successfully built. In April 2017, the company's main product, calcium hydroxymethanesulfonate, obtained the GMP certificate for raw materials (Certificate No.: HB20170336). In 2018, the production line of 60 tons of high sulfuric acid was built and put into production. In 2019, the production lines of 20 tons of colchosterol and 300 tons of betaine were successfully built and put into production, forming a new trend of project diversification and product diversification in the pharmaceutical field of our company.
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